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Hepatocyte NADPH Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice

BACKGROUND & AIMS: Reactive oxidative species (ROS) are believed to be involved in the progression of non-alcoholic steatohepatitis (NASH). However, little is known about the sources of ROS in hepatocytes or their role in disease progression. We studied the effects of NADPH oxidase 4 (NOX4) in l...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Bettaieb, Ahmed, Jiang, Joy X., Sasaki, Yu, Chao, Tzu-I, Kiss, Zsofia, Chen, Xiangling, Tian, Jijing, Katsuyama, Masato, Yabe-Nishimura, Chihiro, Xi, Yannan, Szyndralewiez, Cedric, Schröder, Kathrin, Shah, Ajay, Brandes, Ralph P., Haj, Fawaz G., Török, Natalie J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516583/
https://ncbi.nlm.nih.gov/pubmed/25888330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2015.04.009
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