Presenilin-2 dampens intracellular Ca(2+) stores by increasing Ca(2+) leakage and reducing Ca(2+) uptake

We have previously shown that familial Alzheimer’s disease mutants of presenilin-2 (PS2) and, to a lesser extent, of presenilin-1 (PS1) lower the Ca(2+) concentration of intracellular stores. We here examined the mechanism by which wild-type and mutant PS2 affect store Ca(2+) handling. By using HeLa...

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Bibliographic Details
Published in:J Cell Mol Med
Main Authors: Brunello, Lucia, Zampese, Enrico, Florean, Cristina, Pozzan, Tullio, Pizzo, Paola, Fasolato, Cristina
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516491/
https://ncbi.nlm.nih.gov/pubmed/19382908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00755.x
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