Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex

During nuclear DNA replication, proofreading-deficient DNA polymerase α (Pol α) initiates Okazaki fragment synthesis with lower fidelity than bulk replication by proofreading-proficient Pol δ or Pol ε. Here, we provide evidence that the exonuclease activity of mammalian flap endonuclease (FEN1) exci...

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Gepubliceerd in:EMBO J
Hoofdauteurs: Liu, Songbai, Lu, Guojun, Ali, Shafat, Liu, Wenpeng, Zheng, Li, Dai, Huifang, Li, Hongzhi, Xu, Hong, Hua, Yuejin, Zhou, Yajing, Ortega, Janice, Li, Guo-Min, Kunkel, Thomas A, Shen, Binghui
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Ltd 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516434/
https://ncbi.nlm.nih.gov/pubmed/25921062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489865
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