Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2

Lat1 (SLC7A5) is an amino acid transporter often required for tumor cell import of essential amino acids (AA) including Methionine (Met). Met is the obligate precursor of S-adenosylmethionine (SAM), the methyl donor utilized by all methyltransferases including the polycomb repressor complex (PRC2)-s...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Dann, Stephen G, Ryskin, Michael, Barsotti, Anthony M, Golas, Jonathon, Shi, Celine, Miranda, Miriam, Hosselet, Christine, Lemon, Luanna, Lucas, Judy, Karnoub, Maha, Wang, Fang, Myers, Jeremy S, Garza, Scott J, Follettie, Maximillian T, Geles, Kenneth G, Klippel, Anke, Rollins, Robert A, Fantin, Valeria R
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516430/
https://ncbi.nlm.nih.gov/pubmed/25979827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488166
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