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An Enzyme-sensitive PEG Hydrogel Based on Aggrecan Catabolism for Cartilage Tissue Engineering

A new cartilage-specific degradable hydrogel based on photoclickable thiol-ene PEG hydrogels is presented. The hydrogel crosslinks are composed of the peptide, CRDTEGE-ARGSVIDRC, derived from the aggrecanase-cleavable site in aggrecan. This new hydrogel is evaluated for use in cartilage tissue engin...

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Bibliografske podrobnosti
izdano v:Adv Healthc Mater
Main Authors: Skaalure, Stacey C., Chu, Stanley, Bryant, Stephanie J.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516272/
https://ncbi.nlm.nih.gov/pubmed/25296398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201400277
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