Different Stability and Proteasome-Mediated Degradation Rate of SMN Protein Isoforms

The key pathogenic steps leading to spinal muscular atrophy (SMA), a genetic disease characterized by selective motor neuron degeneration, are not fully clarified. The full-length SMN protein (FL-SMN), the main protein product of the disease gene SMN1, plays an established role in the cytoplasm in s...

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Udgivet i:PLoS One
Main Authors: Locatelli, Denise, Terao, Mineko, Kurosaki, Mami, Zanellati, Maria Clara, Pletto, Daniela Rita, Finardi, Adele, Colciaghi, Francesca, Garattini, Enrico, Battaglia, Giorgio Stefano
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516248/
https://ncbi.nlm.nih.gov/pubmed/26214005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134163
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