Axon outgrowth and neuronal differentiation defects after a-SMN and FL-SMN silencing in primary hippocampal cultures

Spinal Muscular Atrophy (SMA) is a severe autosomal recessive disease characterized by selective motor neuron degeneration, caused by disruptions of the Survival of Motor Neuron 1 (Smn1) gene. The main product of SMN1 is the full-length SMN protein (FL-SMN), that plays an established role in mRNA sp...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Pletto, Daniela, Capra, Silvia, Finardi, Adele, Colciaghi, Francesca, Nobili, Paola, Battaglia, Giorgio Stefano, Locatelli, Denise, Cagnoli, Cinzia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001960/
https://ncbi.nlm.nih.gov/pubmed/29902268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0199105
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