Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats.

Type II diabetic Goto-Kakizaki (GK) rats were insulin-resistant in euglycemic-hyperinsulinemic clamp studies. We therefore examined insulin signaling systems in control Wistar and diabetic GK rats. Glycerol-3-phosphate acyltransferase (G3PAT), which is activated by headgroup mediators released from...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Farese, R V, Standaert, M L, Yamada, K, Huang, L C, Zhang, C, Cooper, D R, Wang, Z, Yang, Y, Suzuki, S, Toyota, T
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1994
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45162/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7972005/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.23.11040
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