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Enhanced Phosphorylation-Independent Arrestins and Gene Therapy
A variety of heritable and acquired disorders is associated with excessive signaling by mutant or overstimulated GPCRs. Since any conceivable treatment of diseases caused by gain-of-function mutations requires gene transfer, one possible approach is functional compensation. Several structurally dist...
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| Veröffentlicht in: | Handb Exp Pharmacol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4516159/ https://ncbi.nlm.nih.gov/pubmed/24292828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-3-642-41199-1_7 |
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