Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

OBJECTIVES: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches. METHODS: Epigenetically regulated expression of DIO2 was explored by a...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Bomer, Nils, den Hollander, Wouter, Ramos, Yolande F M, Bos, Steffan D, van der Breggen, Ruud, Lakenberg, Nico, Pepers, Barry A, van Eeden, Annelies E, Darvishan, Arash, Tobi, Elmar W, Duijnisveld, Bouke J, van den Akker, Erik B, Heijmans, Bastiaan T, van Roon-Mom, Willeke MC, Verbeek, Fons J, van Osch, Gerjo J V M, Nelissen, Rob G H H, Slagboom, P Eline, Meulenbelt, Ingrid
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2015
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516000/
https://ncbi.nlm.nih.gov/pubmed/24695009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2013-204739
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