Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

OBJECTIVES: To investigate how the genetic susceptibility gene DIO2 confers risk to osteoarthritis (OA) onset in humans and to explore whether counteracting the deleterious effect could contribute to novel therapeutic approaches. METHODS: Epigenetically regulated expression of DIO2 was explored by a...

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Bibliografische gegevens
Gepubliceerd in:Ann Rheum Dis
Hoofdauteurs: Bomer, Nils, den Hollander, Wouter, Ramos, Yolande F M, Bos, Steffan D, van der Breggen, Ruud, Lakenberg, Nico, Pepers, Barry A, van Eeden, Annelies E, Darvishan, Arash, Tobi, Elmar W, Duijnisveld, Bouke J, van den Akker, Erik B, Heijmans, Bastiaan T, van Roon-Mom, Willeke MC, Verbeek, Fons J, van Osch, Gerjo J V M, Nelissen, Rob G H H, Slagboom, P Eline, Meulenbelt, Ingrid
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMJ Publishing Group 2015
Onderwerpen:
Basic and Translational Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516000/
https://ncbi.nlm.nih.gov/pubmed/24695009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2013-204739
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