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An ultra-tolerant database search reveals that a myriad of modified peptides contributes to unassigned spectra in shotgun proteomics

Fewer than half of all tandem mass spectrometry (MS/MS) spectra acquired in shotgun proteomics experiments are typically matched to a peptide with high confidence. Here we determine the identity of unassigned peptides using an ultra-tolerant Sequest database search that allows peptide matching even...

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Publicado en:Nat Biotechnol
Autores principales: Chick, Joel M., Kolippakkam, Deepak, Nusinow, David P., Zhai, Bo, Rad, Ramin, Huttlin, Edward L., Gygi, Steven P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515955/
https://ncbi.nlm.nih.gov/pubmed/26076430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3267
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