Expansion of CTG18.1 Trinucleotide Repeat in TCF4 Is a Potent Driver of Fuchs' Corneal Dystrophy

PURPOSE: To analyze the expansion of CTG18.1 allele associated with Fuchs' corneal dystrophy (FCD) in our large cohort of late-onset FCD cases. METHODS: CTG repeats within the CTG18.1 allele were estimated by short tandem repeat (STR) and triplet primed PCR (TP-PCR) assays in our large cohort o...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Vasanth, Shivakumar, Eghrari, Allen O., Gapsis, Briana C., Wang, Jiangxia, Haller, Nicolas F., Stark, Walter J., Katsanis, Nicholas, Riazuddin, S. Amer, Gottsch, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2015
Assuntos:
Cornea
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515948/
https://ncbi.nlm.nih.gov/pubmed/26200491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-16122
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