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Structural prerequisites for G-protein activation by the neurotensin receptor
We previously determined the structure of neurotensin receptor NTSR1 in an active-like conformation with six thermostabilizing mutations bound to the peptide agonist neurotensin. This receptor was unable to activate G proteins, indicating that the mutations restricted NTSR1 to relate agonist binding...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4515772/ https://ncbi.nlm.nih.gov/pubmed/26205105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8895 |
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