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Structural prerequisites for G-protein activation by the neurotensin receptor

We previously determined the structure of neurotensin receptor NTSR1 in an active-like conformation with six thermostabilizing mutations bound to the peptide agonist neurotensin. This receptor was unable to activate G proteins, indicating that the mutations restricted NTSR1 to relate agonist binding...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Krumm, Brian E., White, Jim F., Shah, Priyanka, Grisshammer, Reinhard
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515772/
https://ncbi.nlm.nih.gov/pubmed/26205105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8895
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