Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex.

Type II topoisomerases are the targets of several classes of chemotherapeutic agents that stabilize an intermediate of the catalytic cycle with the enzyme covalently linked to cleaved DNA. We have used 3-azido-AMSA [4'-(3-azido-9-acridinylamino)methanesulfon-m-anisidide], a photo-activatible analog...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Freudenreich, C H, Kreuzer, K N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45155/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7971998/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.23.11007
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