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AMELIORATING TREATMENT-REFRACTORY DEPRESSION WITH INTRANASAL KETAMINE: POTENTIAL NMDA RECEPTOR ACTIONS IN THE PAIN CIRCUITRY REPRESENTING MENTAL ANGUISH

This paper reviews the anti-depressant actions of the N-methyl-D-aspartame glutamate receptor (NMDAR) antagonist, ketamine, and offers a potential neural mechanism for intranasal ketamine’s ultra-rapid actions based on the key role of NMDAR in the nonhuman primate prefrontal cortex (PFC). Although i...

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Dettagli Bibliografici
Pubblicato in:CNS Spectr
Autori principali: Opler, Lewis A., Opler, Mark G., Arnsten, Amy F.T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4515405/
https://ncbi.nlm.nih.gov/pubmed/25619798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S1092852914000686
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