Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation

OBJECTIVE: Inflammatory bowel diseases (IBDs) feature multiple cellular stress responses, including endoplasmic reticulum (ER) unfolded protein responses (UPRs). UPRs represent autoregulatory pathways that adjust organelle capacity to cellular demand. A similar mechanism, mitochondrial UPR (mtUPR),...

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發表在:Gut
Main Authors: Rath, Eva, Berger, Emanuel, Messlik, Anja, Nunes, Tiago, Liu, Bo, Kim, Sandy C, Hoogenraad, Nick, Sans, Miquel, Sartor, R Balfour, Haller, Dirk
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4514769/
https://ncbi.nlm.nih.gov/pubmed/21997551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2011-300767
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