Transcriptional Response of Human Neurospheres to Helper-Dependent CAV-2 Vectors Involves the Modulation of DNA Damage Response, Microtubule and Centromere Gene Groups

Brain gene transfer using viral vectors will likely become a therapeutic option for several disorders. Helper-dependent (HD) canine adenovirus type 2 vectors (CAV-2) are well suited for this goal. These vectors are poorly immunogenic, efficiently transduce neurons, are retrogradely transported to af...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Piersanti, Stefania, Burla, Romina, Licursi, Valerio, Brito, Catarina, La Torre, Mattia, Alves, Paula M., Simao, Daniel, Mottini, Carla, Salinas, Sara, Negri, Rodolfo, Tagliafico, Enrico, Kremer, Eric J., Saggio, Isabella
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4514711/
https://ncbi.nlm.nih.gov/pubmed/26207738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133607
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