Variable epitope library carrying heavily mutated survivin-derived CTL epitope variants as a new class of efficient vaccine immunogen tested in a mouse model of breast cancer

The antigenic variability of tumor cells leading to dynamic changes in cancer epitope landscape along with escape from immune surveillance by down-regulating tumor antigen expression/presentation and immune tolerance are major obstacles for the design of effective vaccines. We have developed a novel...

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Detalhes bibliográficos
Publicado no:Hum Vaccin Immunother
Main Authors: NoeDominguez-Romero, Allan, Zamora-Alvarado, Rubén, Servín-Blanco, Rodolfo, Pérez-Hernández, Erendira G, Castrillon-Rivera, Laura E, Munguia, Maria Elena, Acero, Gonzalo, Govezensky, Tzipe, Gevorkian, Goar, Manoutcharian, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4514078/
https://ncbi.nlm.nih.gov/pubmed/25483665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.29679
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