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DNA hairpins destabilize duplexes primarily by promoting melting rather than by inhibiting hybridization
The effect of secondary structure on DNA duplex formation is poorly understood. Using oxDNA, a nucleotide level coarse-grained model of DNA, we study how hairpins influence the rate and reaction pathways of DNA hybridzation. We compare to experimental systems studied by Gao et al. (1) and find that...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4513862/ https://ncbi.nlm.nih.gov/pubmed/26056172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv582 |
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