DNA hairpins destabilize duplexes primarily by promoting melting rather than by inhibiting hybridization

The effect of secondary structure on DNA duplex formation is poorly understood. Using oxDNA, a nucleotide level coarse-grained model of DNA, we study how hairpins influence the rate and reaction pathways of DNA hybridzation. We compare to experimental systems studied by Gao et al. (1) and find that...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Schreck, John S., Ouldridge, Thomas E., Romano, Flavio, Šulc, Petr, Shaw, Liam P., Louis, Ard A., Doye, Jonathan P.K.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Computational Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513862/
https://ncbi.nlm.nih.gov/pubmed/26056172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv582
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker