Partitioning between recoding and termination at a stop codon–selenocysteine insertion sequence

Selenocysteine (Sec) is inserted into proteins by recoding a UGA stop codon followed by a selenocysteine insertion sequence (SECIS). UGA recoding by the Sec machinery is believed to be very inefficient owing to RF2-mediated termination at UGA. Here we show that recoding efficiency in vivo is 30–40%...

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Publicat a:Nucleic Acids Res
Autors principals: Kotini, Suresh Babu, Peske, Frank, Rodnina, Marina V.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513850/
https://ncbi.nlm.nih.gov/pubmed/26040702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv558
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