Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
E2F-1 is a transcription factor suspected of activating genes required for S phase and a known target for the action of RB, the retinoblastoma gene product. Its induction in quiescent fibroblasts led to S-phase entry followed by apoptosis. E2F-1-mediated apoptosis was suppressed by coexpression of w...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1994
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45137/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7971984/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.23.10918 |
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