Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

E2F-1 is a transcription factor suspected of activating genes required for S phase and a known target for the action of RB, the retinoblastoma gene product. Its induction in quiescent fibroblasts led to S-phase entry followed by apoptosis. E2F-1-mediated apoptosis was suppressed by coexpression of w...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Qin, X Q, Livingston, D M, Kaelin, W G, Adams, P D
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1994
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45137/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7971984/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.23.10918
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