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The polyclonal CD8 T cell response to influenza M1(58–66) generates a fully connected network of cross-reactive clonotypes to structurally related peptides: A paradigm for memory repertoire coverage of novel epitopes or escape mutants()
Cross-reactivity of T cells is defined by recognition of two or more peptide-MHC complexes by the same T cell. Although examples of cross-reactivity have been reported, a detailed examination of cross-reactivity has not been performed. Here we take advantage of the high degree of polyclonality in th...
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| Publicado no: | J Immunol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4513670/ https://ncbi.nlm.nih.gov/pubmed/21518969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1004031 |
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