Early increase in circulating carbonic anhydrase IX during neoadjuvant treatment predicts favourable outcome in locally advanced rectal cancer

BACKGROUND: Locally advanced rectal cancer (LARC) comprises heterogeneous tumours with predominant hypoxic components. The hypoxia-inducible metabolic shift causes microenvironmental acidification generated by carbonic anhydrase IX (CAIX) and facilitates metastatic progression, the dominant cause of...

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Enregistré dans:
Détails bibliographiques
Publié dans:BMC Cancer
Auteurs principaux: Hektoen, Helga Helseth, Flatmark, Kjersti, Andersson, Yvonne, Dueland, Svein, Redalen, Kathrine Røe, Ree, Anne Hansen
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513373/
https://ncbi.nlm.nih.gov/pubmed/26205955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1557-6
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