Early increase in circulating carbonic anhydrase IX during neoadjuvant treatment predicts favourable outcome in locally advanced rectal cancer

BACKGROUND: Locally advanced rectal cancer (LARC) comprises heterogeneous tumours with predominant hypoxic components. The hypoxia-inducible metabolic shift causes microenvironmental acidification generated by carbonic anhydrase IX (CAIX) and facilitates metastatic progression, the dominant cause of...

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Publicado en:BMC Cancer
Autores principales: Hektoen, Helga Helseth, Flatmark, Kjersti, Andersson, Yvonne, Dueland, Svein, Redalen, Kathrine Røe, Ree, Anne Hansen
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513373/
https://ncbi.nlm.nih.gov/pubmed/26205955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1557-6
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