Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

Intact interkeulin-10 receptor (IL-10R) signaling on effector and regulatory T (Treg) cells are each independently required to maintain immune tolerance. Here we show that IL-10 sensing by innate immune cells, independent of its effects on T cells, was critical for regulating mucosal homeostasis. Fo...

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Publicado no:Immunity
Main Authors: Shouval, Dror S., Biswas, Amlan, Goettel, Jeremy A., McCann, Katelyn, Conaway, Evan, Redhu, Naresh S., Mascanfroni, Ivan D., Adham, Ziad Al, Lavoie, Sydney, Ibourk, Mouna, Nguyen, Deanna D., Samsom, Janneke N., Escher, Johanna C., Somech, Raz, Weiss, Batia, Beier, Rita, Conklin, Laurie, Ebens, Christen L., Santos, Fernanda GMS, Ferreira, Alexandre R., Sherlock, Mary, Bhan, Atul K., Müller, Werner, Mora, J. Rodrigo, Quintana, Francisco J., Klein, Christoph, Muise, Aleixo M., Horwitz, Bruce H., Snapper, Scott B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513358/
https://ncbi.nlm.nih.gov/pubmed/24792912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.03.011
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