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Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis
The actin cytoskeleton is important for platelet biogenesis. Tropomodulin-3 (Tmod3), the only Tmod isoform detected in platelets and megakaryocytes (MKs), caps actin filament (F-actin) pointed ends and binds tropomyosins (TMs), regulating actin polymerization and stability. To determine the function...
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| Veröffentlicht in: | Blood |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4513252/ https://ncbi.nlm.nih.gov/pubmed/25964668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-09-601484 |
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