New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C

Kinesin-13 proteins depolymerize microtubules in an ATP hydrolysis-dependent manner. The coupling between these two activities remains unclear. Here, we first studied the role of the kinesin-13 subfamily-specific loop 2 and of the KVD motif at the tip of this loop. Shortening the loop, the lysine/gl...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wang, Weiyi, Shen, Ting, Guerois, Raphael, Zhang, Fuming, Kuerban, Hureshitanmu, Lv, Yuncong, Gigant, Benoît, Knossow, Marcel, Wang, Chunguang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513128/
https://ncbi.nlm.nih.gov/pubmed/26055718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.646919
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