Differential Regulation of Multiple Steps in Inositol 1,4,5-Trisphosphate Signaling by Protein Kinase C Shapes Hormone-stimulated Ca(2+) Oscillations

How Ca(2+) oscillations are generated and fine-tuned to yield versatile downstream responses remains to be elucidated. In hepatocytes, G protein-coupled receptor-linked Ca(2+) oscillations report signal strength via frequency, whereas Ca(2+) spike amplitude and wave velocity remain constant. IP(3) u...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Bartlett, Paula J., Metzger, Walson, Gaspers, Lawrence D., Thomas, Andrew P.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513112/
https://ncbi.nlm.nih.gov/pubmed/26078455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.657767
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