Mucosal Immunization with Newcastle Disease Virus Vector Coexpressing HIV-1 Env and Gag Proteins Elicits Potent Serum, Mucosal, and Cellular Immune Responses That Protect against Vaccinia Virus Env and Gag Challenges

Newcastle disease virus (NDV) avirulent strain LaSota was used to coexpress gp160 Env and p55 Gag from a single vector to enhance both Env-specific and Gag-specific immune responses. The optimal transcription position for both Env and Gag genes in the NDV genome was determined by generating recombin...

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Опубликовано в: :mBio
Главные авторы: Khattar, Sunil K., Manoharan, Vinoth, Bhattarai, Bikash, LaBranche, Celia C., Montefiori, David C., Samal, Siba K.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Microbiology 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513081/
https://ncbi.nlm.nih.gov/pubmed/26199332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01005-15
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