Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury

BACKGROUND: Mechanical stress induced by injurious ventilation leads to pro-inflammatory cytokine production and lung injury. The extracellular-signal-regulated-kinase, ERK1/2, participates in the signaling pathways activated upon mechanical stress in the lungs to promote the inflammatory response....

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Detalhes bibliográficos
Publicado no:Intensive Care Med Exp
Main Authors: Kaniaris, Evangelos, Vaporidi, Katerina, Vergadi, Eleni, Theodorakis, Emmanuel E, Kondili, Eumorfia, Lagoudaki, Eleni, Tsatsanis, Christos, Georgopoulos, Dimitris
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513004/
https://ncbi.nlm.nih.gov/pubmed/26266915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2197-425X-2-15
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