Calcium desensitisation in late polymicrobial sepsis is associated with loss of vasopressor sensitivity in a murine model

BACKGROUND: Sepsis is characterised by diminished vasopressor responsiveness. Vasoconstriction depends upon a balance: Ca(2+)-dependent myosin light-chain kinase promotes and Ca(2+)-independent myosin light-chain phosphatase (MLCP) opposes vascular smooth muscle contraction. The enzyme Rho kinase (R...

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Bibliografiska uppgifter
I publikationen:Intensive Care Med Exp
Huvudupphovsmän: Reddi, Benjamin AJ, Beltrame, John F, Young, Richard L, Wilson, David P
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer International Publishing 2015
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512972/
https://ncbi.nlm.nih.gov/pubmed/26215803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-014-0036-8
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