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Calcium desensitisation in late polymicrobial sepsis is associated with loss of vasopressor sensitivity in a murine model
BACKGROUND: Sepsis is characterised by diminished vasopressor responsiveness. Vasoconstriction depends upon a balance: Ca(2+)-dependent myosin light-chain kinase promotes and Ca(2+)-independent myosin light-chain phosphatase (MLCP) opposes vascular smooth muscle contraction. The enzyme Rho kinase (R...
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| Publicado no: | Intensive Care Med Exp |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4512972/ https://ncbi.nlm.nih.gov/pubmed/26215803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-014-0036-8 |
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