Smad3 Signaling Promotes Fibrosis, While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice

BACKGROUND: Heart failure in diabetics is associated with cardiac hypertrophy, fibrosis and diastolic dysfunction. Activation of transforming growth factor (TGF)-β/Smad3 signaling in the diabetic myocardium may mediate fibrosis and diastolic heart failure, while preserving matrix homeostasis. We hyp...

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Bibliografiska uppgifter
I publikationen:Circ Heart Fail
Huvudupphovsmän: Biernacka, Anna, Cavalera, Michele, Wang, Junhong, Russo, Ilaria, Shinde, Arti, Kong, Ping, Gonzalez-Quesada, Carlos, Rai, Vikrant, Dobaczewski, Marcin, Lee, Dong-Wook, Wang, Xiao-Fan, Frangogiannis, Nikolaos G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512850/
https://ncbi.nlm.nih.gov/pubmed/25985794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.114.001963
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