Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection

Impaired immune responses in the elderly lead to reduced vaccine efficacy and increased susceptibility to viral infections. Although several groups have documented age-dependent defects in adaptive immune priming, the deficits that occur prior to antigen encounter remain largely unexplored. Herein,...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Richner, Justin M., Gmyrek, Grzegorz B., Govero, Jennifer, Tu, Yizheng, van der Windt, Gerritje J. W., Metcalf, Talibah U., Haddad, Elias K., Textor, Johannes, Miller, Mark J., Diamond, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512688/
https://ncbi.nlm.nih.gov/pubmed/26204259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005027
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