Transcriptome outlier analysis implicates schizophrenia susceptibility genes and enriches putatively functional rare genetic variants

We searched a gene expression dataset comprised of 634 schizophrenia (SZ) cases and 713 controls for expression outliers (i.e., extreme tails of the distribution of transcript expression values) with SZ cases overrepresented compared with controls. These outlier genes were enriched for brain express...

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Pubblicato in:Hum Mol Genet
Autori principali: Duan, Jubao, Sanders, Alan R., Moy, Winton, Drigalenko, Eugene I., Brown, Eric C., Freda, Jessica, Leites, Catherine, Göring, Harald H. H., Gejman, Pablo V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512633/
https://ncbi.nlm.nih.gov/pubmed/26022996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv199
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