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Immune function in mice lacking the perforin gene.

Mice lacking the perforin gene were generated by using targeted gene disruption in embryonal stem cells. When infected with lymphocytic choriomeningitis virus (LCMV), perforin-less (-/-) mice showed clear signs of having mounted an immune response based on activation of CD8 T cells but were unable t...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Walsh, C M, Matloubian, M, Liu, C C, Ueda, R, Kurahara, C G, Christensen, J L, Huang, M T, Young, J D, Ahmed, R, Clark, W R
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45124/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7526382/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.23.10854
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