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Large-scale epigenome imputation improves data quality and disease variant enrichment

With hundreds of epigenomic maps, the opportunity arises to exploit the correlated nature of epigenetic signals, across both marks and samples, for large-scale prediction of additional datasets. Here, we undertake epigenome imputation by leveraging such correlations through an ensemble of regression...

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Pubblicato in:Nat Biotechnol
Autori principali: Ernst, Jason, Kellis, Manolis
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512306/
https://ncbi.nlm.nih.gov/pubmed/25690853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3157
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