Structural analysis of leader peptide binding enables leader-free cyanobactin processing

Regioselective modification of amino acids within the context of a peptide is common to a number of biosynthetic pathways and many such products have potential as therapeutics. The ATP dependent enzyme LynD heterocyclizes multiple cysteine residues to thiazolines within a peptide substrate. The enzy...

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Veröffentlicht in:Nat Chem Biol
Hauptverfasser: Koehnke, Jesko, Mann, Greg, Bent, Andrew F, Ludewig, Hannes, Shirran, Sally, Botting, Catherine, Lebl, Tomas, Houssen, Wael, Jaspars, Marcel, Naismith, James H
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512242/
https://ncbi.nlm.nih.gov/pubmed/26098679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1841
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