Role of diffuse low-level heteroplasmy of mitochondrial DNA in Alzheimer’s disease neurodegeneration

Alzheimer’s disease (AD) is the most common form of dementia in the elderly. The vast majority of cases are not linked to a known genetic defect and the molecular mechanisms underlying AD pathogenesis are still elusive. Evidence suggests that mitochondrial dysfunction is a prominent feature of the d...

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Bibliographic Details
Published in:Front Aging Neurosci
Main Authors: Casoli, Tiziana, Spazzafumo, Liana, Di Stefano, Giuseppina, Conti, Fiorenzo
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511837/
https://ncbi.nlm.nih.gov/pubmed/26257647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2015.00142
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