HDAC8, A Potential Therapeutic Target for the Treatment of Malignant Peripheral Nerve Sheath Tumors (MPNST)

INTRODUCTION: HDAC isoform-specific inhibitors may improve the therapeutic window while limiting toxicities. Developing inhibitors against class I isoforms poses difficulties as they share high homology among their catalytic sites; however, HDAC8 is structurally unique compared to other class I isof...

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發表在:PLoS One
Main Authors: Lopez, Gonzalo, Bill, Kate Lynn J., Bid, Hemant Kumar, Braggio, Danielle, Constantino, Dylan, Prudner, Bethany, Zewdu, Abeba, Batte, Kara, Lev, Dina, Pollock, Raphael E.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511720/
https://ncbi.nlm.nih.gov/pubmed/26200462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133302
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