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Structural and Physico-Chemical Effects of Disease and Non-Disease nsSNPs on Proteins

This review emphasizes the effects of naturally occurring mutations on structural features and physico-chemical properties of proteins. The basic protein characteristics considered are stability, dynamics, and the binding of proteins and methods for assessing effects of mutations on these macromolec...

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Detalhes bibliográficos
Publicado no:Curr Opin Struct Biol
Main Authors: Kucukkal, Tugba G, Petukh, Marharyta, Li, Lin, Alexov, Emil
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511717/
https://ncbi.nlm.nih.gov/pubmed/25658850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2015.01.003
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