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Endolysosomal Deficits Augment Mitochondria Pathology in Spinal Motor Neurons of Asymptomatic fALS Mice
One pathological hallmark in ALS motor neurons (MNs) is axonal accumulation of damaged mitochondria. A fundamental question remains: does reduced degradation of those mitochondria by impaired autophagy-lysosomal system contribute to mitochondrial pathology? Here, we reveal MN-targeted progressive ly...
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| Gepubliceerd in: | Neuron |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4511489/ https://ncbi.nlm.nih.gov/pubmed/26182418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.06.026 |
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