Belinostat, a potent HDACi, exerts antileukaemic effect in human acute promyelocytic leukaemia cells via chromatin remodelling

Epigenetic changes play a significant role in leukaemia pathogenesis, therefore histone deacetylases (HDACis) are widely accepted as an attractive strategy for acute promyelocytic leukaemia (APL) treatment. Belinostat (Bel, PXD101), a hydroxamate-type HDACi, has proved to be a promising cure in clin...

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Pubblicato in:J Cell Mol Med
Autori principali: Valiuliene, Giedre, Stirblyte, Ieva, Cicenaite, Dovile, Kaupinis, Algirdas, Valius, Mindaugas, Navakauskiene, Ruta
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Ltd 2015
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511371/
https://ncbi.nlm.nih.gov/pubmed/25864732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12550
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