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Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermis

Merkel cells are mechanosensitive skin cells whose production requires the basic helix-loop-helix transcription factor Atoh1. We induced ectopic Atoh1 expression in the skin of transgenic mice to determine whether Atoh1 was sufficient to create additional Merkel cells. In embryos, ectopic Atoh1 expr...

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Publicado en:Development
Autores principales: Ostrowski, Stephen M., Wright, Margaret C., Bolock, Alexa M., Geng, Xuehui, Maricich, Stephen M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510865/
https://ncbi.nlm.nih.gov/pubmed/26138479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.123141
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