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Bryostatin activates HIV-1 latent expression in human astrocytes through a PKC and NF-ĸB-dependent mechanism

Multiple studies have shown that HIV-1 patients may develop virus reservoirs that impede eradication; these reservoirs include the central nervous system (CNS). Despite an undetectable viral load in patients treated with potent antiretrovirals, current therapy is unable to purge the virus from these...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Díaz, Laura, Martínez-Bonet, Marta, Sánchez, Javier, Fernández-Pineda, Alejandra, Jiménez, José Luis, Muñoz, Eduardo, Moreno, Santiago, Álvarez, Susana, Muñoz-Fernández, Mª Ángeles
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510492/
https://ncbi.nlm.nih.gov/pubmed/26199173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12442
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