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Compstatin analog Cp40 inhibits complement dysregulation in vitro in C3 glomerulopathy

C3 glomerulopathy (C3G) defines a group of untreatable ultra-rare renal diseases caused by uncontrolled activation of the alternative complement pathway. Nearly half of patients progress to end stage renal failure within 10 years. Cp40, a second-generation compstatin analog in clinical development,...

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Publicat a:Immunobiology
Autors principals: Zhang, Yuzhou, Shao, Dingwu, Ricklin, Daniel, Hilkin, Brieanna M., Nester, Carla M., Lambris, John D., Smith, Richard J. H.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510458/
https://ncbi.nlm.nih.gov/pubmed/25982307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imbio.2015.04.001
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