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Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation

Dysfunction of the autophagy-lysosomal pathway (ALP) and the ubiquitin-proteasome system (UPS) was thought to be an important pathogenic mechanism in synuclein pathology and Parkinson's disease (PD). In the present study, we investigated the role of sestrin2 in autophagic degradation of α-synuc...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Biol
Prif Awduron: Hou, Yi-Sheng, Guan, Jun-Jie, Xu, Hai-Dong, Wu, Feng, Sheng, Rui, Qin, Zheng-Hong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508325/
https://ncbi.nlm.nih.gov/pubmed/26031332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00285-15
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