Protective role of 5-azacytidine on myocardial infarction is associated with modulation of macrophage phenotype and inhibition of fibrosis

We examined whether a shift in macrophage phenotype could be therapeutic for myocardial infarction (MI). The mouse macrophage cell line RAW264.7 was stimulated with peptidoglycan (PGN), with or without 5-azacytidine (5AZ) treatment. MI was induced by ligation of the left anterior descending coronary...

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Bibliographic Details
Published in:J Cell Mol Med
Main Authors: Kim, Yong Sook, Kang, Wan Seok, Kwon, Jin Sook, Hong, Moon Hwa, Jeong, Hye-yun, Jeong, Hae Chang, Jeong, Myung Ho, Ahn, Youngkeun
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2014
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508142/
https://ncbi.nlm.nih.gov/pubmed/24571348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12248
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